Natural dicarbonyls inhibit peroxidase activity of peroxiredoxins
نویسندگان
چکیده
منابع مشابه
Comparative analysis of cyanobacterial and plant peroxiredoxins and their electron donors: peroxidase activity and susceptibility to overoxidation.
Peroxiredoxins (Prxs) are peroxidases that use thiol-based catalytic mechanisms implying redox-active cysteines. The different Prx families have homologs in all photosynthetic organisms, including plants, algae, and cyanobacteria. However, recent studies show that the physiological reduction systems that provide Prxs with reducing equivalents to sustain their activities differ considerably betw...
متن کاملUtilizing Natural and Engineered Peroxiredoxins As Intracellular Peroxide Reporters
It is increasingly apparent that nature evolved peroxiredoxins not only as H2O2 scavengers but also as highly sensitive H2O2 sensors and signal transducers. Here we ask whether the H2O2 sensing role of Prx can be exploited to develop probes that allow to monitor intracellular H2O2 levels with unprecedented sensitivity. Indeed, simple gel shift assays visualizing the oxidation of endogenous 2-Cy...
متن کاملThe conformational bases for the two functionalities of 2-cysteine peroxiredoxins as peroxidase and chaperone
2-Cysteine peroxiredoxins (2-CysPrxs) are ubiquitous and highly abundant proteins that serve multiple functions as peroxidases, chaperones, and thiol oxidases and in redox-dependent cell signalling. The chloroplast protein plays a role in seedling development and protection of the photosynthetic apparatus. This study aimed to unequivocally link conformation and function. To this end, a set of n...
متن کاملPeroxiredoxins in colorectal neoplasms.
Peroxiredoxins (Prxs) are novel group proteins with efficient antioxidant capacity, and some of them also have effects on cell proliferation, differentiation, apoptosis, and chemotherapy and radiotherapy resistance. Altogether six distinct Prxs expressions were investigated in histological samples of colorectal neoplasm and the distant normal tissues and investigated associatedly with parameter...
متن کاملPeroxiredoxins in parasites.
SIGNIFICANCE Parasite survival and virulence relies on effective defenses against reactive oxygen and nitrogen species produced by the host immune system. Peroxiredoxins (Prxs) are ubiquitous enzymes now thought to be central to such defenses and, as such, have potential value as drug targets and vaccine antigens. RECENT ADVANCES Plasmodial and kinetoplastid Prx systems are the most extensive...
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ژورنال
عنوان ژورنال: Доклады Академии наук
سال: 2019
ISSN: 0869-5652
DOI: 10.31857/s0869-56524853377-380